Nguyen TK Thanh Mae
Prof. Thanh held a University Research Fellowship (2005-2014) and Professor of Nanomaterials at the UCL Healthcare Biomagnetic and Nanomaterials Laboratories and Department of Physics & Astronomy, University College London. In 1992, she received the award for top academic achievement in Chemistry at Vietnam National University in Hanoi and was selected to study at the University of Amsterdam under a NUFFIC (the Netherlands organization for international cooperation in higher education) program, which marked the start of her research career. In 1994, she was selected for an EUfunded PhD position in Biochemistry. She developed a method to analyze different types of lipids in rat kidney...
Nguyen TK Thanh Mae
Mini BioProf. Thanh held a University Research Fellowship (2005-2014) and Professor of Nanomaterials at the UCL Healthcare Biomagnetic and Nanomaterials Laboratories and Department of Physics & Astronomy, University College London. In 1992, she received the award for top academic achievement in Chemistry at Vietnam National University in Hanoi and was selected to study at the University of Amsterdam under a NUFFIC (the Netherlands organization for international cooperation in higher education) program, which marked the start of her research career. In 1994, she was selected for an EUfunded PhD position in Biochemistry. She developed a method to analyze different types of lipids in rat kidney and urine to study the renal toxicity of Nphenyl anthranilic acid, an agent inducing renal papillary necrosis, and mefenamic acid, a nonsteroidal anti-inflammatory and analgesic drug. The outcome was that lipids could be used as a non-invasive marker for renal papillary necrosis, a major disease caused by long-term abuse of analgesic drugs. In 1999, she undertook postdoctoral work in medicinal chemistry at Aston University and developed a method to synthesize new cell membranepermeable fluorescent analogs of the cyclic nucleotide second messengers, cAMP and cGMP, as sensors to study cellular mechanisms of memory storage. This first postdoc period provided her with advanced practical experience in chemical synthesis, which proved very valuable for her later research in nanotechnology. In 2001, she moved to the United States to take advantage of pioneering work in nanotechnology, an emerging and rapidly growing field of science. She brought together her previous skills to synthesize nanoparticlebased sensors for biological assays. An important feature of this first phase of work in Bio Nanotechnology was the demonstration of the power of nanotechnological tools to simplify conventional bioanalytical assays, which resulted in substantial cost and time savings at the point of use. She developed a unique, sensitive, and highly specific immunoassay system for antibodies using Au nanoparticles (NPs). This baptism in nanotechnology in the USA gave her an insight into the field and convinced her that this was where her future lay. In 2003, there was an opportunity for her to move a step forward in gaining an independent research career in nanotechnology, when she joined the Liverpool Center for Nanoscale Science. This position has provided a strong interdisciplinary environment (e.g., PGNOW for glycosaminoglycan studies, cancer research and tissue engineering), in which she has gained knowledge of biomolecular sciences, and developed close collaborations with those interested in applying these new approaches to the study of biological problems. She has also established strong collaborations with physicists in the UK and abroad to study the physical properties of NPs (e.g., magnetic order within individual Co NPs and magnetic interactions between them). In 2005, she was awarded a prestigious Royal Society University Research Fellowship and University of Liverpool lectureship. She was based at the Department of Chemistry (ranked 7th in the UK in 2008 RAE) and School of Biological Sciences. In January 2009, she was appointed a UCL-RI Readership in Nanotechnology and based at The Davy Faraday Research Laboratory, The Royal Institution of Great Britain, London, UK. She leads a research team focused on the design, synthesis, and study of the physical properties of nanomaterials as well as their applications in biomolecular and biomedical research. In 2013, she was promoted to a Professor of Nanomaterials and based at UCL Healthcare Biomagnetic and Nanomaterials Laboratories, at the Royal Institution, and the Department of Physics and Astronomy, University College London. She leads a very dynamic research group conducting cutting-edge interdisciplinary research on the design and synthesis of nanomaterials for biomedical applications. She is Editor-in-Chief of the Royal Society of Chemistry book Series, Nanoscience and Nanotechnology, and Associate Editor of the Nanoscale and Nanoscale Advances Journals (2024- present). Prof. Thanh has more than 246 papers published in peer-reviewed journals, 26630 citations, and a h-index of 49.
Nanomaterials for the Future
The strategic engineering of advanced nanomaterials is a cornerstone of next-generation healthcare technologies. Among these, plasmonic and magnetic nanomaterials have emerged as powerful platforms because of their unique optical, electronic, and magnetic behaviors at the nanoscale. By combining these properties, researchers can design smart, multifunctional systems that bridge the gap between diagnosis and therapy (theranostics). This innovative research leverages the synergistic effects of noble metals and magnetic oxides to overcome the limitations of conventional medicine, offering highly precise, minimally invasive solutions for early disease detection and targeted cancer treatments. The four pillars of the research framework are:
1. Design: Conceptualizing complex hybrid architectures (such as core-shell, heterodimers, or branched structures) to maximize synergy between magnetic and plasmonic fields while ensuring longterm colloidal stability.
2. Synthesis: Utilizing advanced chemical routes (including thermal decomposition, co-precipitation, and microfluidic synthesis) to achieve rigorous, reproducible control over the size, shape, and crystallinity of the nanoparticles.
3. Characterization: Employing state-of-the-art analytical tools—such as Transmission Electron Microscopy (TEM), X-ray Diffraction (XRD), and SQUID magnetometry—to assess physical metrics and validate precise structure-property relationships.
4. Biofunctionalization: Engineering the nanoparticle surface with biocompatible polymers (e.g., PEG) and specific targeting ligands (antibodies, peptides, or aptamers) to evade immune clearance andselectively bind to molecular biomarkers.
The lecture will cover examples and applications of magnetic and metallic nanoparticles.